Set in downtown New York in 1900, the Knickerbocker Hospital faces a major upheaval due to poor finances and an exodus of wealthy patients. The one remaining star is Dr. Thackeray, who along with the hospital staff of surgeons, nurses and other personnel must struggle to keep both themselves and the hospital going.

Reunite with the perplexing and prickly Dr. Gregory House as he tackles impossible cases while putting a new staff of potential team members through the medical wringer with his trademark sarcasm and irreverent bedside manner.

Dr. Gregory House and his hand-picked team of young medical experts will do whatever it takes to solve the puzzles that other doctors give up on.

Jackie Peyton is a sharp-tongued and quick-witted nurse who is trying to survive the chaotic grind of saving lives in a hectic New York City hospital. Jackie's a woman of substance who knows how to handle it all. With a white lie here, a bent rule there, and a steady dose of pain relievers for her chronic back pain, Jackie does whatever it takes to get the job done.

Jackie Peyton is a sharp-tongued and quick-witted nurse who is trying to survive the chaotic grind of saving lives in a hectic New York City hospital. Jackie's a woman of substance who knows how to handle it all. With a white lie here, a bent rule there, and a steady dose of pain relievers for her chronic back pain, Jackie does whatever it takes to get the job done.

Dr. Gregory House is devoid of bedside manner and wouldn't even talk to his patients if he could get away with it. Dealing with his own constant physical pain and ignoring his pain killing addiction, he uses his cane to punctuate his acerbic, brutally honest demeanor. House and his team deal with unusual medical mysteries.

Paramedics of Los Angeles County Fire Dept. Station 51, John Gage and Roy DeSoto, respond to emergencies ranging from false alarms to major disasters. Since the paramedic program is still a relatively recent service, the paramedics must be guided by licensed medical personnel through radio contact on site. The staff of Rampart Hospital, with doctors Brackett and Early as well as Head Nurse McCall, provides the necessary instructions for the paramedics...